Volumetric analyses have been performed on MRI scans obtained at the time of study entry from the first 77 participants enrolled in the MRI portion of the MCI protocol. Fifty-eight percent of these participants are men and 42% are women. They have a mean age of 73 years and a mean education of 15 years. They have a mean score of 28 on the Mini-Mental Status Examination (MMSE) (Folstein, Folstein, & McHugh, 1975), a mean score of 11 on the ADAS-COG, and a mean score of 1.8 on the CDR Sum of Boxes.
We performed correlational analyses between the MRI hippocampal volumes at study entry and the participants' concurrent performance on (ADAS-COG) and functional (CDR Sum of Boxes) measures. The results indicate that hippocampal volume in these participants predicted performance on the ADAS-COG (r = -.31, P < .01) and the CDR Sum of Boxes (r = -.33, P < .01). These correlations remained significant after controlling for age and gender. The relationships are shown graphically in Figures 5.1 and 5.2. For illustration purposes, the MRI hippocampal volumes are divided into tertiles from smallest to highest.
We performed correlational analyses between the MRI hippocampal volumes at study entry and the participants' concurrent performance on (ADAS-COG) and functional (CDR Sum of Boxes) measures. The results indicate that hippocampal volume in these participants predicted performance on the ADAS-COG (r = -.31, P < .01) and the CDR Sum of Boxes (r = -.33, P < .01). These correlations remained significant after controlling for age and gender. The relationships are shown graphically in Figures 5.1 and 5.2. For illustration purposes, the MRI hippocampal volumes are divided into tertiles from smallest to highest.
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