The four techniques for evaluation were chosen based upon their demonstrated usefulness in evaluating medial temporal atrophy. These include:
1. The volumetric assessment technique of the Mayo group (Jack et al.,1990,1992).
2. The qualitative assessment of medial temporal lobe atrophy performed by the NYU group (de Leon et al., 1993,1989,1997).
3. The linear assessment technique of Jobst et al. (1998,1992).
4. The three-dimensional (3-D) mapping technique employed at UCLA (Thomspon & Toga, 1996; Thompson et al., 1996). The centers participating in this multisite protocol who share both common MCI definitions and MRI acquisition sequences are listed in Table6.1, along with the number of MCIs and controls to be studied.