Methandrostenolone was first developed in the 1950s and was soon a favorite among all kinds of athletes. This is due in large part to the fact that it is both easy to use and highly effective. In the US, production had a dramatic history, climbing for years, then dropping almost instantly in the 1980s when it was decided that Methandrostenolone 10mg tabs held no value for the medical community and it was removed from pharmacy shelves
Even so, the popularity of Methandrostenolone tablets continues, it remains the most widely used oral anabolic steroid in the US. As long as it is being made in any country, it will likely remain just as popular as it is now.
It is a highly potent steroid, similar to testosterone or Anadrol, but it has some potentially negative side effects. To begin, Methandrostenolone is highly estrogenic and gynecomastia (enlarged breast tissue in men) is a concern that can present quite early in a cycle, especially at higher doses. Another major concern is water retention, which can cause a significant loss in muscle definition due to increased water and fat. Individuals who are sensitive to estrogens may want to add an anti estrogen like Nolvadex or Proviron, or even stronger drugs like Arimidex, Femara, or Aromasin, if any of these are available.
Androgenic side effects are also quite common with Methandrostenolone, including oily skin, acne, and facial and body hair. Aggressive behavior is also fairly common with these kinds of steroids, so it is important to keep your temper in check during a cycle. Individuals who are genetically predisposed to male pattern baldness may also experience hair loss and may prefer to go with a milder anabolic steroid, such as Deca Durabolin, to prevent this. While Methandrostenolone can convert to a more powerful steroid by interacting with 5-alpha reductase enzyme, the same enzyme that converts testosterone to dihydrotestosterone, it does so only in trace amounts, so using Proscar or Propecia with Methandrostenolone is generally unhelpful.
Because Methandrostenolone is moderately androgenic, it is better suited to male athletes than females. When used by women, it has the potential for strong virilization effects, or the appearance of masculine characteristics in women. Some women do experiment with low doses of Methandrostenolone pills, typically 5 mg, and frequently do see dramatic muscle grown.
Anytime you take Methandrostenolone, you will see significant gains in muscle mass and strength. Its potency is frequently compared with other steroids such as testosterone and Anadrol 50, making it incredibly popular for bulking cycles. A daily dose of 20-40 mg is sufficient to offer results to even highly experienced users. There are users who take doses much higher than this, but this is unwise due to the increased potential for serious negative side effects.
Methandrostenolone also stacks well with most other steroids. It goes especially well with the mild anabolic steroid Deca Durabolin. Taking these two together can provide amazing gains in size and strength, without adding side effects beyond those generally seen with it alone. For maximum mass building, use a long acting testosterone, such as enanthate. Because it has such high estrogenic and androgenic properties similar to Methandrostenolone, the potential for side effects is quite a bit higher, but the huge gains in mass may make it worth the risk for some users. There are, however, drugs that can be used in conjunction with these that can reduce some of these side effects.
In order to be orally active, Methandrostenolone 10mg tablets are c17 alpha-alkylated. Essentially what this means is that it is chemically altered to allow it to pass through the liver without being denatured, so that it reaches the bloodstream in an active state. The downside to this is that the process that allows the steroid to survive passing through the liver also makes it toxic to the liver. Short term exposure can lead to elevated liver enzymes, while prolonged use can cause liver damage.
People with compromised livers should avoid Methandrostenolone, and anyone taking Methandrostenolone should limit cycles to no more than 6-8 weeks. It is also a good idea to see a doctor when taking Methandrostenolone so that liver enzyme levels can be monitored. The first visible indication of liver damage is jaundice, a yellowing of the skin and eyes as the liver has trouble effectively processing bilirubin. In the event this happens, stop using Methandrostenolone immediately and seek medical attention
It is interesting that Methandrostenolone is molecularly similar to boldenone, except for the chemical alteration previously discussed. The main difference between these two seems to be the estrogenic side effects, which are more pronounced with Methandrostenolone. Equipoise is relatively mild and generally does not require the addition of an anti-estrogen.
However, it is significantly more powerful at increasing muscle mass than boldenone, which suggests that estrogen is an integral part of anabolism. In fact, these two substances are so dissimilar that they are rarely thought of as being comparable. Because of this, Methandrostenolone is generally limited to use in bulking phases, while Equipoise is preferred for cutting phases or for building lean muscle mass.
The half life of Methandrostenolone tablets is relatively short compared to other steroids, about 3-4 hours. This means that taking it once a day causes blood levels to spike, then drop through the day. Many users will split their daily dose and take it two or even three times through the day. This has the benefit of keeping levels more steady through the day. The downside to this is the levels don’t get as high as they do when it’s taken all at once.
Knowing that blood levels of Methandrostenolone 10mg peak about 2-3 hours after taking it, the question is when is the best time to take it. It seems that taking it earlier in the day, preferably before working would, might be best. This allows for several daytime hours for the androgen driven metabolism to increase absorption of nutrients, especially following training.
Stacking and Dosage Timing
It has been established that at a daily dose of 50 mg taken in the morning, it causes minimal HPTA impairment. When using Methandrostenolone as part of a stack, it is generally recommended that it be taken in smaller doses spread throughout the day due to its relatively low half life of 3-4 hours.
When it comes to the pharmacological properties of Methandrostenolone tablets 10mg, it only weakly interacts with the androgen receptors and binds poorly to the receptors. It stands to reason, then, that much of the value of Methandrostenolone comes from effects that are not related to the androgen receptors. It does synergize well with Trenbolone, a Class I steroid, and is categorized as a Class II steroid. It also stacks well with Primobolan and Deca Durabolin.
On the other hand, Methandrostenolone does not stack well with Anadrol. These two work in very similar ways, so they do not synergize well. Also, Anadrol can aggravate estrogen related side effects. Bottom line, it stacks well with testosterone and with Class I steroids. Methandrostenolone tabs are converted via aromatase to methylestradiol. Adding Arimidex or letrozole to the stack can help to minimize this conversion. If conversion is to be allowed, Clomid or Nolvadex can block the side effects.