Friday, March 27, 2015

Using Methandrostenolone Tablets 10mg for Bodybuilding Cycles

Methandrostenolone was first developed in the 1950s and was soon a favorite among all kinds of athletes. This is due in large part to the fact that it is both easy to use and highly effective. In the US, production had a dramatic history, climbing for years, then dropping almost instantly in the 1980s when it was decided that Methandrostenolone 10mg tabs held no value for the medical community and it was removed from pharmacy shelves

Even so, the popularity of Methandrostenolone tablets continues, it remains the most widely used oral anabolic steroid in the US. As long as it is being made in any country, it will likely remain just as popular as it is now.

It is a highly potent steroid, similar to testosterone or Anadrol, but it has some potentially negative side effects. To begin, Methandrostenolone is highly estrogenic and gynecomastia (enlarged breast tissue in men) is a concern that can present quite early in a cycle, especially at higher doses. Another major concern is water retention, which can cause a significant loss in muscle definition due to increased water and fat. Individuals who are sensitive to estrogens may want to add an anti estrogen like Nolvadex or Proviron, or even stronger drugs like Arimidex, Femara, or Aromasin, if any of these are available.

Androgenic side effects are also quite common with Methandrostenolone, including oily skin, acne, and facial and body hair. Aggressive behavior is also fairly common with these kinds of steroids, so it is important to keep your temper in check during a cycle. Individuals who are genetically predisposed to male pattern baldness may also experience hair loss and may prefer to go with a milder anabolic steroid, such as Deca Durabolin, to prevent this. While Methandrostenolone can convert to a more powerful steroid by interacting with 5-alpha reductase enzyme, the same enzyme that converts testosterone to dihydrotestosterone, it does so only in trace amounts, so using Proscar or Propecia with Methandrostenolone is generally unhelpful.

Because Methandrostenolone is moderately androgenic, it is better suited to male athletes than females. When used by women, it has the potential for strong virilization effects, or the appearance of masculine characteristics in women. Some women do experiment with low doses of Methandrostenolone pills, typically 5 mg, and frequently do see dramatic muscle grown.

Anytime you take Methandrostenolone, you will see significant gains in muscle mass and strength. Its potency is frequently compared with other steroids such as testosterone and Anadrol 50, making it incredibly popular for bulking cycles. A daily dose of 20-40 mg is sufficient to offer results to even highly experienced users. There are users who take doses much higher than this, but this is unwise due to the increased potential for serious negative side effects.

Methandrostenolone also stacks well with most other steroids. It goes especially well with the mild anabolic steroid Deca Durabolin. Taking these two together can provide amazing gains in size and strength, without adding side effects beyond those generally seen with it alone. For maximum mass building, use a long acting testosterone, such as enanthate. Because it has such high estrogenic and androgenic properties similar to Methandrostenolone, the potential for side effects is quite a bit higher, but the huge gains in mass may make it worth the risk for some users. There are, however, drugs that can be used in conjunction with these that can reduce some of these side effects.

In order to be orally active, Methandrostenolone 10mg tablets are c17 alpha-alkylated. Essentially what this means is that it is chemically altered to allow it to pass through the liver without being denatured, so that it reaches the bloodstream in an active state. The downside to this is that the process that allows the steroid to survive passing through the liver also makes it toxic to the liver. Short term exposure can lead to elevated liver enzymes, while prolonged use can cause liver damage.

People with compromised livers should avoid Methandrostenolone, and anyone taking Methandrostenolone should limit cycles to no more than 6-8 weeks. It is also a good idea to see a doctor when taking Methandrostenolone so that liver enzyme levels can be monitored. The first visible indication of liver damage is jaundice, a yellowing of the skin and eyes as the liver has trouble effectively processing bilirubin. In the event this happens, stop using Methandrostenolone immediately and seek medical attention

It is interesting that Methandrostenolone is molecularly similar to boldenone, except for the chemical alteration previously discussed. The main difference between these two seems to be the estrogenic side effects, which are more pronounced with Methandrostenolone. Equipoise is relatively mild and generally does not require the addition of an anti-estrogen.

However, it is significantly more powerful at increasing muscle mass than boldenone, which suggests that estrogen is an integral part of anabolism. In fact, these two substances are so dissimilar that they are rarely thought of as being comparable. Because of this, Methandrostenolone is generally limited to use in bulking phases, while Equipoise is preferred for cutting phases or for building lean muscle mass.

The half life of Methandrostenolone tablets is relatively short compared to other steroids, about 3-4 hours. This means that taking it once a day causes blood levels to spike, then drop through the day. Many users will split their daily dose and take it two or even three times through the day. This has the benefit of keeping levels more steady through the day. The downside to this is the levels don’t get as high as they do when it’s taken all at once.

Knowing that blood levels of Methandrostenolone 10mg peak about 2-3 hours after taking it, the question is when is the best time to take it. It seems that taking it earlier in the day, preferably before working would, might be best. This allows for several daytime hours for the androgen driven metabolism to increase absorption of nutrients, especially following training.

Stacking and Dosage Timing

It has been established that at a daily dose of 50 mg taken in the morning, it causes minimal HPTA impairment. When using Methandrostenolone as part of a stack, it is generally recommended that it be taken in smaller doses spread throughout the day due to its relatively low half life of 3-4 hours.

When it comes to the pharmacological properties of Methandrostenolone tablets 10mg, it only weakly interacts with the androgen receptors and binds poorly to the receptors. It stands to reason, then, that much of the value of Methandrostenolone comes from effects that are not related to the androgen receptors. It does synergize well with Trenbolone, a Class I steroid, and is categorized as a Class II steroid. It also stacks well with Primobolan and Deca Durabolin.

On the other hand, Methandrostenolone does not stack well with Anadrol. These two work in very similar ways, so they do not synergize well. Also, Anadrol can aggravate estrogen related side effects. Bottom line, it stacks well with testosterone and with Class I steroids. Methandrostenolone tabs are converted via aromatase to methylestradiol. Adding Arimidex or letrozole to the stack can help to minimize this conversion. If conversion is to be allowed, Clomid or Nolvadex can block the side effects.

Friday, March 20, 2015

Ipamorelin: Potent Peptide For Building More Muscle

Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.

Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?

Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.

Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.

In one experiment, various doses were administered over the course of 15 days to test the group's reactions.

There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.

The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH. This is actually a good thing as it suggests that Ipamorelin may not decrease your body's natural GH production - further demonstrating that Ipamorelin is a selective GH releaser.

GHRP-6Unlike GHRP-6, Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet. And obviously, Ipamorelin's side-effects are enhanced when combined with anabolic steroids since they too influence Growth Hormone/Insulin Growth Factor release and production.

In another study in rats, Ipamorelin released GH from rat pituitary cells as effectively as GHRP-6.

Another document states that in healthy swine, Ipamorelin released GH with a consistency that is very comparable to GHRP-6. Also noteworthy was that none of the GH releasers tested affected FSH, LH, PRL or TSH blood serum plasma levels.

Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.

This clearly proves that Ipamorelin is the first successful GHRP receptor agonist or chemical that binds to a receptor of a cell and triggers a response by that cell with a specific selectivity for the promotion of GH release by itself.

Another advantage to Ipamorelin is that it doesn't cause sudden spikes in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is slower in its delivery unlike GHRP's which spike GH levels at a more rapid rate. The slower release is more natural and has a more sustained effect.

All in all it looks as if Ipamorelin is the new wave in GH releasing peptides. It appear to be more potent, longer lasting and potentially safer to use in the long run. More studies are being conducted all the time but as it stands, Ipamorelin looks like a serious contender in the arsenal of anabolic advancement.

Wednesday, March 4, 2015

Testosterone Cypionate & Enanthate vs Slower Ester Test Undecanoate

Testosterone injections deliver testosterone deep into the muscle. The testosterone is then absorbed directly into the blood stream over time. The absorption period depends on the type of testosterone injected. Injections usually take place in the thighs, glutes or deltoid muscles.The most common forms of injectable testosterone for Testosterone Replacement Therapy (TRT) available in the US have long half-lives. These forms include Testosterone Enanthate and Testosterone Cypionate. Due to their long half-lives, both Testosterone Enanthate and Testosterone Cypionate provide a sustained release of testosterone into the bloodstream for 2 to 3 weeks. As a result, testosterone injections need only be administered every week or every other week. The most commonly recommended dosing regimen for TRT is 100 to 200 mg every 2 weeks. Approximately 30% of men treated for low testosterone use testosterone injections.

Testosterone Enanthate and Testosterone Cypionate

Testosterone enanthate and Testosterone Cypionate are modified forms of testosterone. Specifically, a carboxylic acid ester has been added to the 17-beta hydroxyl group. This attachment makes Testosterone Enanthate and Testosterone Cypionate less polar than free testosterone. As a result, they have longer half-lives and are absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed to yield free (active) testosterone. Their slow-acting nature allows for less frequent testosterone injections. Specifically, Testosterone Enanthate possesses a half-life of roughly 8-10 days. Testosterone Cypionate possesses a half-life of roughly 10-12 days. Therefore, it takes approximately 8 to 10 days for the body to metabolize and clear half the concentration of the testosterone enanthate following an injection. As a result, users may go two weeks between injections. Since injectable testosterone has been around for so long, generic versions of these medications are available.

Two Potential Down Sides of Testosterone Enanthate and Testosterone Cypionate Testosterone Injections

Unfortunately, testosterone injections do not mimic physiologic dosing. As a result, testosterone  levels can fluctuate in the period between injections. Fluctuations in testosterone are not ideal. These fluctuations can affect mood, emotional stability, and sexual activity. Following an injection of Testosterone Enanthate or Testosterone Cypionate, testosterone levels exceed normal physiological levels for the first 2 to 3 days. They then steadily decline to levels below physiological levels just prior to the next injection. Shortening the interval between testosterone injections and lowering the dose can minimize this cyclical nature of highs and lows. Nevertheless, these peaks and troughs still exist. Fortunately, another testosterone ester, Testosterone Undecanoate, has been approved that maintains testosterone levels in normal ranges.

In addition to not mimicking physiologic dosing, injectable testosterone also show a stronger impact on raising red blood cell levels than transdermal options. One of the more concerning potential side effects of TRT is an increase in red blood cells. Testosterone stimulates the production of red blood cells. In most cases the increase in red blood cells is small (2-5%) and within a safe range. However, for a considerable number of TRT users, testosterone injections produce red blood cell levels above safe levels over 50%. This increase in red blood cells causes your blood to become more viscous. Blood that is too viscous increases your risk of forming blood clots, which can subsequently lead to a heart attack and/or stroke.

Recently, the US FDA approved injectable Testosterone Undecanoate (2014). Testosterone undecanoate is very slow acting. The drug provides a sustained release of testosterone into the bloodstream for up to 10 weeks.

Testosterone levels fluctuate between Testosterone Enanthate and Testosterone Cypionate testosterone injections. This results in more negative side effects than administration methods that provide more stable blood testosterone concentrations. Shortening the interval between injections can minimize this cyclical nature of highs and lows. It also can be achieved by lowering the dose. The longer lasting version of injectable testosterone, Testosterone Undecanoate, maintains testosterone levels in normal ranges. Testosterone injections are more likely to cause an increased red blood cell count than other forms. Injection site pain is relatively common. Need to visit a physician for testosterone injections if unable to self-administer at home.

The primary difference between esters is the rate at which testosterone enters the bloodstream following an injection. A slower release means fewer testosterone injections per year. Testosterone propionate is a fast-acting ester rarely used in TRT. Testosterone Enanthate and Testosterone Cypionate are slow-acting injectable forms. They have been the predominant form used for TRT. Testosterone Undecanoate is a newly approved form that is very slow acting.

Testosterone Cypionate is a slow-acting injectable form of the androgen testosterone. Following deep intramuscular injection, the drug provides a sustained release of testosterone into the bloodstream for 2 to 3 weeks. Testosterone Cypionate possesses a half-life of 10-12 days. The most commonly recommended dosing regimen for TRT is 100 mg to 200 mg every 2 weeks. Typically, 26 injections are required per year.

Testosterone Enanthate

Similar to Testosterone Cypionate, Testosterone Enanthate is a slow-acting injectable form of the androgen testosterone. Following deep intramuscular injection, Testosterone Enanthate provides a sustained release of testosterone into the bloodstream for 2 to 3 weeks. Testosterone Enanthate possesses a half-life of 8-10 days. The most commonly recommended dosing regimen for TRT is 100 mg to 200 mg every 2 weeks. Typically, 26 injections are required per year.

Testosterone Propionate

In comparison to Testosterone Enanthate and Testosterone Cypionate, Testosterone Propionate is a faster-acting form of the androgen testosterone. Testosterone Propionate possesses a half-life of roughly 1-2 days. Therefore, Testosterone Propionate does not provide a sustained release. Due to this short half-life, it must be injected every other or every third day. As a result, it is rarely used for TRT.