Showing posts with label Letrozole. Show all posts
Showing posts with label Letrozole. Show all posts

Wednesday, February 19, 2014

How Much Arimidex or Letrozole Is Needed on a Testosterone Cycle?


Initial values to try, I figure a base of 0.36 mg/day for letrozole where no testosterone is being taken but there is a need to reduce high or moderately high estradiol OR 0.36 mg for each 200 or 250 mg/week of testosterone that is being taken, but not more than 1.0 mg/day as the initial value and typically not as an adjusted value either.

The numbers don’t need to be that precise. The 0.36 value results simply from 2.5 mg/week being divided into 7 parts.

Dosing also can be every other day instead of daily, provided the total weekly dosage is the same.

With Arimidex I never developed an adjusted-for-testosterone-amount method, but have recommended 0.5 mg every other day and adjusting from there. This also works.

For your proposed cycle, it would be the 1.0 mg letrozole per day figure, as 700 mg/week is about 3 times the 200-250 mg/week figure, and multiplying 0.36 mg by three gets us up to the 1.0 mg/day suggested initial-dose ceiling — but there should be a follow-up test of estradiol levels. Or if not doing that — the test isn’t expensive though and results are back quickly — then at least being ready to reduce if there are symptoms suggesting low estradiol: joint problems, depression, or low libido.

But it is better to get the actual test because the absence of those symptoms doesn’t prove that estradiol hasn’t been driven too low. There could still be a problem.

And likewise, having one or more of those symptoms doesn’t prove estradiol has been driven too low, either. It is only suggestive. But if one finds from experience that changing aromatase inhibitor amount clearly matches up with change in the symptoms, then that is a good basis for adjustment. Still (repeating myself) better to get the test.

Thursday, February 6, 2014

Letrozole by QD Labs - reduce estrogens with unmatched efficacy


In the world of professional sports, particularly bodybuilding and strength athletics, Letrozole or Femara is an admired name. This wonder drug is second to none when it comes to the treatment of infertility for inducing ovulation.

Letrozole, which is also known as Femara, is used in the world of anabolic steroids and performance enhancing drugs as a powerful antiestrogen. In the world of healthcare, it is used to treat spread of breast cancer after standard options of treatment such as Tamoxifen therapy have failed.

The chemical name of Letrozole is 4,4′-(1H-1,2,4Triazol-1-ylmethylene)dibenzonitrile and its molecular formula is C17H11N 5. This drug has the molecular weight of 285.31 g/mol at the base.

Sportsmen, especially steroid users, prefer Letrozole over other antiestrogens as it can inhibit the formation of estrogens by as much as 98 percent. In addition to that, Letrozole can enhance the levels of follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin significantly. Moreover, steroid users can easily avoid steroid side effects such as oily skin, acne, gynecomastia, and water retention by using Letrozole.

The recommended dose of Letrozole (Femara) is 2.5 mg per day and this antiestrogen is best taken at the end of a steroid cycle. It is important to note that this antiestrogen is not recommended for pregnant and breastfeeding women or those using heavy machinery or performing activities requiring complete attention as its use can lead to dizziness. In order to maintain its shelf life, Letrozole is best stored at a controlled temperature of 25°C (77°F) with excursions permitted up to 15-30°C (59-86°F).